| Primary Identifier | MGI:5788667 | Allele Type | Targeted |
| Attribute String | Conditional ready, No functional change | Gene | Sod2 |
| Transmission | Germline | Strain of Origin | Not Specified |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The endogenous gene was modified in mouse embryonic stem cells by inserting a PGK/neo cassette between exons 3 and 4. LoxP sites were inserted 3' of exon 1 and 5' of exon 4, such that Cre-mediated recombination will remove exons 2 and 3. Exon 3 is crucial for manganese binding and homotetramer formation, and thus recombination is expected to completely inactivate Sod2. |
