| Primary Identifier | MGI:5800408 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(PDGFB-LRRK2*R1441C)31Hlw |
| Strain of Origin | FVB/N | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Human LRRK2 with the disease causing R1441C mutation with an HA tag on the C-terminus is under the control of the CMV enhancer/platelet-derived growth factor-beta chain promoter. Immunoblot analysis confirmed transgene expression in various brain regions, including the cerebral cortex, substantia nigra, and striatum. Western blot analysis indicates a 2-fold overexpression of the protein compared to the endogenous level in the substantia nigra. Two lines, 31 and 39, were established and line 31 is entered as the representative line. |
