| Primary Identifier | MGI:5818723 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Gabrg2 |
| Transmission | Germline | Strain of Origin | (C57BL/6J x 129)F1 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A loxP site flanked neomycin resistance gene cassette was inserted into intron 8 and exon 9 was replaced with a version with an engineered C1165T point mutation. The point mutation gives rise to the mouse equivalent of the Dravet syndrome-associated human Q390X nonsense mutation (Q389X in mouse) in the encoded peptide. The neo cassette was removed through cre-mediated recombination. |
