| Primary Identifier | MGI:5819099 | Allele Type | Endonuclease-mediated |
| Attribute String | Null/knockout | Gene | Prnp |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | A TALEN pair was used to target a site in close proximity to the start codon. An 8-bp deletion was identified in exon 3. The frame shift introduced a premature stop codon in the sequence coding for the secretory signal peptide. Homozygous mice show no detectable protein expression in central nervous system (CNS) tissues, as assessed by Western blotting. |
