| Primary Identifier | MGI:5823275 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Sgpp2 |
| Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A neomycin selection cassette replaced a genomic fragment containing exons 3 and 4. Various tissues of homozygous mice failed to express detectable transcripts, as detected by semiquantitative real-time PCR. Total sphingosine-1-phosphate phosphatase (SPPase) enzymatic activity was decreased by ~30% in the membrane fraction from homozygous mutant lung tissue. |
