| First Author | Methot L | Year | 2018 |
| Journal | Glia | Volume | 66 |
| Issue | 12 | Pages | 2659-2672 |
| PubMed ID | 30338559 | Mgi Jnum | J:268795 |
| Mgi Id | MGI:6269709 | Doi | 10.1002/glia.23518 |
| Citation | Methot L, et al. (2018) Nuclear factor-kappaB regulates multiple steps of gliogenesis in the developing murine cerebral cortex. Glia 66(12):2659-2672 |
| abstractText | Nuclear factor-kappaB (NF-kappaB) is activated in neural progenitor cells in the developing murine cerebral cortex during the neurogenic phase, when it acts to prevent premature neuronal differentiation. Here we show that NF-kappaB activation continues in mouse neocortical neural progenitor cells during the neurogenic-to-gliogenic switch. Blockade of endogenous NF-kappaB activity during neocortical gliogenesis leads to the formation of supernumerary committed gliogenic progenitors and premature glial cell differentiation. Conversely, forced NF-kappaB activation during the neocortical neurogenic-to-gliogenic transition causes delayed gliogenic commitment and decreased astroglial gene expression. NF-kappaB activation continues in neocortical gliogenic progenitors following commitment and is important to inhibit the differentiation of oligodendrocyte precursor cells and to maintain persistent expression of glial fibrillary acidic protein in maturing astrocytes. These results reveal a number of previously uncharacterized roles for NF-kappaB during different phases of neocortical gliogenesis and identify NF-kappaB as an inhibitor of early oligodendrocyte development in the cerebral cortex. |
