| First Author | Methot L | Year | 2013 |
| Journal | Mol Cell Biol | Volume | 33 |
| Issue | 14 | Pages | 2797-808 |
| PubMed ID | 23689134 | Mgi Jnum | J:204476 |
| Mgi Id | MGI:5532628 | Doi | 10.1128/MCB.01610-12 |
| Citation | Methot L, et al. (2013) Interaction and antagonistic roles of NF-kappaB and Hes6 in the regulation of cortical neurogenesis. Mol Cell Biol 33(14):2797-808 |
| abstractText | The involvement of nuclear factor kappa B (NF-kappaB) in several processes in the postnatal and adult brain, ranging from neuronal survival to synaptogenesis and plasticity, has been documented. In contrast, little is known about the functions of NF-kappaB during embryonic brain development. It is shown here that NF-kappaB is selectively activated in neocortical neural progenitor cells in the developing mouse telencephalon. Blockade of NF-kappaB activity leads to premature cortical neuronal differentiation and depletion of the progenitor cell pool. Conversely, NF-kappaB activation causes decreased cortical neurogenesis and expansion of the progenitor cell compartment. These effects are antagonized by the proneuronal transcription factor Hes6, which physically and functionally interacts with RelA-containing NF-kappaB complexes in cortical progenitor cells. In turn, NF-kappaB exerts an inhibitory effect on the ability of Hes6 to promote cortical neuronal differentiation. These results reveal previously uncharacterized functions and modes of regulation for NF-kappaB and Hes6 during cortical neurogenesis. |
