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Allele : Scn5a<tm2.1Tjh> sodium channel, voltage-gated, type V, alpha; targeted mutation 2.1, Thomas J Hund

Primary Identifier  MGI:5825295 Allele Type  Targeted
Gene  Scn5a Transmission  Germline
Strain of Origin  C57BL/6 Is Recombinase  false
Is Wild Type  false
molecularNote  Exon 13 was modified such that an S571A muatation was created in the translated peptide. LoxP sites were inserted in intron 9 and intron 13. An FRT site flanked neomycin resistance gene cassette was inserted between exon 13 and the loxP site. The neo cassette was removed through flp-mediated recombination. The substituted alanine can not be phosphorylated (whereas the original serine can).
  • mutations:
  • Insertion,
  • Nucleotide substitutions
  • synonyms:
  • Scn5a S571A,
  • Scn5a S571A
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories

Trail: Allele