| Primary Identifier | MGI:5829042 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(Thy1-UBQLN2)356Mont |
| Strain of Origin | SJL or C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| description | The transgenic construct was injected into fertilized SJL/C57BL/6J hybrid eggs per the primary investigator. |
| molecularNote | The transgene was designed to have the modified ~6.5 kbp mouse Thy1.2 promoter (Thy1 sequences extending from the promoter to the intron following exon 4, excluding exon 3 and its flanking introns) followed by a cDNA sequence encoding the full-length, wildtype human ubiquilin 2 protein. UBQLN2 missense mutations are linked to dominant inheritance of amyotrophic lateral sclerosis (ALS) with frontotemporal dementia (FTD). Founder line 356 was found to have ~1.5-3.5 copies of the transgene. |
