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Allele : Tg(CAG-cat,-Ptpn11*Q510E)#Krnz transgene insertion, Maike Krenz
Primary Identifier  MGI:5828597 Allele Type  Transgenic
Attribute String  Conditional ready, Inserted expressed sequence Gene  Tg(CAG-cat,-Ptpn11*Q510E)#Krnz
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
molecularNote  The CAG (cytomegalovirus enhancer and chicken beta-actin) promoter was used to drive cre-dependent expression of a modified Ptpn11 gene, which contains the amino acid substitution of glutamate for glutamine at position 510, following removal of an intervening floxed chloramphenicol acetyltransferase (cat) gene. The Q510E mutation is found in patients with aggressive Noonan syndrome with multiple lentigines. The pound symbol (#) is used when line is not specified and/or lines are pooled.
  • mutations:
  • Insertion
  • synonyms:
  • CC-Q510E,
  • CC-Q510E
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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