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Allele : Tg(Ins2-Akt1*)3Mbb transgene insertion 3, Morris J Birnbaum

Primary Identifier  MGI:5829193 Allele Type  Transgenic
Attribute String  Constitutively active, Inserted expressed sequence Gene  Tg(Ins2-Akt1*)3Mbb
Strain of Origin  (C57BL/6 x SJL)F1 Is Recombinase  false
Is Wild Type  false
description  Phenotypic Similarity to Human Syndrome: Insulinoma J:144599.
molecularNote  The rat insulin II promoter drives the expression in pancreatic beta cells a form of Akt1 that has been rendered constitutively active by the addition of an N-terminal myristoylation sequence. Western blot confirmed expression of the transgene in pancreatic lysates. Two lines were generated, F3 and F7.
  • mutations:
  • Insertion
  • synonyms:
  • RIP-MyrAkt1,
  • RIP-MyrAkt1
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

Trail: Allele

1 Driven By

Trail: Allele

5 Publication categories

Trail: Allele