Primary Identifier | MGI:5829193 | Allele Type | Transgenic |
Attribute String | Constitutively active, Inserted expressed sequence | Gene | Tg(Ins2-Akt1*)3Mbb |
Strain of Origin | (C57BL/6 x SJL)F1 | Is Recombinase | false |
Is Wild Type | false |
description | Phenotypic Similarity to Human Syndrome: Insulinoma J:144599. |
molecularNote | The rat insulin II promoter drives the expression in pancreatic beta cells a form of Akt1 that has been rendered constitutively active by the addition of an N-terminal myristoylation sequence. Western blot confirmed expression of the transgene in pancreatic lysates. Two lines were generated, F3 and F7. |