Primary Identifier | MGI:5882714 | Allele Type | Targeted |
Attribute String | Conditional ready, No functional change | Gene | Nfatc1 |
Transmission | Germline | Strain of Origin | Not Specified |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A loxP site, a neomycin resistance gene cassette and a second loxP site were inserted upstream of the alternative P2 promoter in intron 1. A third loxP site was inserted downstream of the promoter. This creates a conditional-ready isoform specific knock-out allele which, upon cre-mediated recombination, would abolish transcription of the betaA, betaB and betaC splice variants. |