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Allele : Tg(Myh6/tetO-Cacnb2*)1Jmol transgene insertion 1, Jeffery Molkentin
Primary Identifier  MGI:5897302 Allele Type  Transgenic
Attribute String  Inducible, Inserted expressed sequence Gene  Tg(Myh6/tetO-Cacnb2*)1Jmol
Strain of Origin  FVB Induced With  doxycycline/tetracycline
Is Recombinase  false Is Wild Type  false
molecularNote  Mice bearing this transgene express a C3S/C4S palmitoylation-deficient mutant form of rat CACNB2 (calcium channel, voltage-dependent, beta 2 subunit; an L-type Ca<2+> channel (LTCC) activator) fused to the canonical caveolin binding domain (CBD; RNVPPIFNDVYWIAF) under the conditional control of the mouse Myh6 (myosin, heavy polypeptide 6, cardiac muscle, alpha) promoter and the tetracycline-responsive element (TRE or tetO). Expression of the transgene is robust as determined by western blot.
  • mutations:
  • Insertion
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0 Mutation Involves

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