| Primary Identifier | MGI:5897311 | Allele Type | Transgenic |
| Attribute String | Inducible, Inserted expressed sequence | Gene | Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol |
| Strain of Origin | FVB | Induced With | doxycycline/tetracycline |
| Is Recombinase | false | Is Wild Type | false |
| description | Transgenic mice exhibit 5% to 10% replacement at baseline in the absence of tTA transgene. |
| molecularNote | Mice bearing this transgene conditionally express FLAG-tagged rat Tnnc1 (troponin C, cardiac/slow skeletal) cDNA carrying an I61Q (ATC->CAG) mutation under the control of the mouse cardiac-specific Myh6 (myosin, heavy polypeptide 6, cardiac muscle, alpha) promoter and the tetracycline responsive element (tetO). The transgene elicits ~45% incorporation of the mutant cardiac troponin C into the cardiac muscle sarcomere. |
