| Primary Identifier | MGI:5896791 | Allele Type | Transgenic |
| Attribute String | Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter | Gene | Tg(CAG-GFP,-EIF4EBP1*)2969Als |
| Strain of Origin | Not Specified | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The transgene has (from 5' to 3') a CMV-IE enhancer/chicken beta-actin/rabbit beta-globin hybrid promoter (from CAGGS), a loxP-GFP-3xSTOP-loxP cassette and a cDNA sequence encoding human EIF4EBP1 rendered constitutively active and mTORC1-nonresponsive by threonine-to-alanine mutations at two mTOR phosphorylation sites [T37A and T46A]). In the absence of Cre recombinase, mice have widespread expression of GFP, and no human EIF4EBP1 expression. |
