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Allele : Mapt<tm1(lacZ,HBEGF/EGFP)Gld> microtubule-associated protein tau; targeted mutation 1, Martyn Goulding
Primary Identifier  MGI:5911677 Allele Type  Targeted
Attribute String  Conditional ready, Inserted expressed sequence, Reporter Gene  Mapt
Transmission  Germline Strain of Origin  129S1/SvImJ
Is Recombinase  false Is Wild Type  false
molecularNote  Sequences encoding for the simian diphtheria toxin receptor (DTR) fused to EGFP and bGH polyA sequences downstream of a double-stop (ds) cassette consisting of a floxed STOP signal and an frt flanked nuclear bata-galactosidase (nlsLacZ) and STOP signal was inserted into Mapt locus. Endogenous Mapt promoter drives expression of nlsLacZ or DTR/EGFP fusion protein. Cre mediated removal of the first STOP signal is required for expression of nlsLacZ. Cre and flp mediated recombination are required to remove both STOP signals to allow for expression of the DTR/EGFP fusion protein.
  • mutations:
  • Insertion
  • synonyms:
  • Tau<ds-DTR>,
  • Mapt<ds-DTR>,
  • Mapt<ds-DTR>,
  • Tau<ds-DTR>
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

24 Publication categories

Trail: Allele




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