| Primary Identifier | MGI:5910352 | Allele Type | Transgenic |
| Attribute String | Dominant negative, Inserted expressed sequence | Gene | Tg(CAMK2A-KCNIP3*,-lacZ)16Cnbc |
| Strain of Origin | (C57BL/6 × CBA)F1 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The cDNA encoding human KCNIP3 (DREAM) with two amino-acid substitutions each at EFhands 2, 3 and 4 (EFmDREAM) was inserted downstream of the human CaMKII promoter. The cDNA was followed by an IRES and the LacZ reporter gene. The amino acid substitutions rendered the mutant insensitive to Ca2+, and thus can block the Ca2+dependent derepression function of DREAM and other KChIP proteins endogenously expressed. |
