| Primary Identifier | MGI:5908700 | Allele Type | Targeted |
| Attribute String | Humanized sequence, Hypomorph | Gene | Ssu2 |
| Transmission | Germline | Strain of Origin | (129S6/SvEvTac x C57BL/6J)F1 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 6 was replaced wiht on in which a point mutation (C to A) results in the amino acid substitution of glutamine for proline at position 141 (P141Q). Cre-mediate recombination removed the floxed neomycin resistance cassette inserted downstream of the modified exon. The modification mimics one identified in human patients with Autosomal-Dominant Dentin Dysplasia Type I. Real-time PCR confirmed reduced transcript expression in the underjaw tissue in homozygotes. |
