| Primary Identifier | MGI:5907163 | Allele Type | Targeted |
| Attribute String | Conditional ready | Gene | Flnc |
| Transmission | Germline | Strain of Origin | C57BL/6 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A stop codon was created by a G to A mutation in exon 48 (W2711X) mimicking the most common myofibrillar myopathy-filaminopathy mutation in man. I addition a loxP site and FRT flanked neo cassette was inserted upstream of exon 47 and a loxP site was inserted the untranslated region of exon 48. Flp mediated recombination removed the neo cassette. RT-PCR analysis indicates mRNA levels are similar to wild-type. Protein levels are also similar to wild-type. |
