Primary Identifier | MGI:5911061 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Ptk2b |
Transmission | Germline | Strain of Origin | Not Specified |
Is Recombinase | false | Is Wild Type | false |
molecularNote | LoxP sites were inserted to flank exons 15-18 and an frt-flanked neomycin selection cassette. Cre-mediated recombination in the germ line resulted in a deletion of the genomic region containing exons 15-18. These exons encode the kinase domain. Western blot and immunohistochemistry studies showed that no detectable encoded protein is expressed from this allele. |