Primary Identifier | MGI:5908882 | Allele Type | Transgenic |
Attribute String | Inserted expressed sequence | Gene | Tg(Rho-GUCY2D*R838S)362Amd |
Strain of Origin | (C57BL/6 x SJL)F2 | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The transgene contains a 4.2-kbp mouse rod opsin gene fragment (harboring the promoter region and the 0.3-kb BGH polyadenylation signal-containing fragment) driving retinal expression of the human gene carrying a point mutation coding for the amino acid substitution of serine for arginine at position 838 (R838S). Lines 379 (slow) and 362 (faster) were generated. |