| Primary Identifier | MGI:5909085 | Allele Type | Transgenic |
| Attribute String | Dominant negative, Inserted expressed sequence | Gene | Tg(Myh7-Ptpn11*Q510E)#Krnz |
| Strain of Origin | FVB/N | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The murine beta-myosin heavy chain promoter drives the expression of a Ptpn11 cDNA which contains the amino acid substitution of glutamate for glutamine at position 510 (Q510E). Q510E is a dominant-negative loss-of-function mutation. The beta-myosin heavy chain promoter drives transgene expression starting around E11 and the transgene is expressed stably and continuously after birth. Several lines were generated including: 1, 3, 5, and 6, however, the pound symbol (#) is used when line is not specified and/or lines are pooled. |
