| Primary Identifier | MGI:5906305 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(Prnp-PFN1)850Kiaei |
| Strain of Origin | C57BL/6N | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The transgenic construct contains an untagged human profilin 1 (PFN1) cDNA sequence (420 bp) under the direction of mouse prion protein promoter. Expression is detected in brain, spinal cord, and to a lesser extent in skeletal muscle. The transgene is not expressed in the liver. Founder line 850 was identified with total PFN1 protein levels in spinal cord at ~4-fold greater levels compared to endogenous mouse PFN1 protein levels in non-transgenic mice. |
