| First Author | Chang B | Year | 2024 |
| Journal | MGI Direct Data Submissioni | Mgi Jnum | J:347588 |
| Mgi Id | MGI:7625640 | Citation | Chang B (2024) B6.Cg-Tg(FXN*)1Sars Fxntm1Mkn rd21/Boc strain details. MGI Direct Data Submissioni |
| abstractText | The retinal degeneration 21 (rd21) heritable mutant phenotype was discovered in our ocular phenotypes screening program in September 2013 in strain B6.Cg-Tg(FXN*)1Sars Fxntm1Mkn/J (JAX Stock No. 008586) that presented with vessel attenuation and retinal degeneration at 36 weeks of age (Chang et al., Invest. Ophthalmol. Vis. Sci.. June 2015; 56(7):2881). We mated the mutant mice with C57BL/6J and all F1 mice had normal retinas. The retinal degeneration phenotype was recovered in the F2 generation then siblings mated to homozygosity. Linkage crosses then showed this spontaneous mutation to be an autosomal recessive mutation that mapped to Chromosome 19 in the same location as the Fxntm1Mkn targeted mutation. We did genotyping on this rd21 phenotypic homozygous strain (JAX Stock No. 036965) and this strain was double homozygous for the Tg(FXN*)1Sars transgene insertion and Fxntm1Mkn targeted mutation. |
