| Primary Identifier | MGI:5919980 | Allele Type | Targeted |
| Attribute String | Dominant negative | Gene | Septin12 |
| Transmission | Germline | Strain of Origin | Not Specified |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Substitutions (c.196AGC>GAG) were engineered in codon 196 in exon 6, changing it from a serine to a glutamate codon (p.Ser196Glu or p.S196E). A loxP site flanked neomycin resistance gene was inserted into intron 7. the neo cassette was removed through subsequent cre-mediated recombination. In the peptide the mutation acts as a phosphomimetic. |
