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Allele : Tg(Foxp3*-cre,-Thy1)#Xzhou transgene insertion, Xuyu Zhou
Primary Identifier  MGI:6117456 Allele Type  Transgenic
Attribute String  Inserted expressed sequence, Recombinase Gene  Tg(Foxp3*-cre,-Thy1)#Xzhou
Strain of Origin  Not Specified Is Recombinase  true
Is Wild Type  false
molecularNote  Transgene consists of the hCre-2A-eqFP650-2A-Thy1.1 cDNA fragment inserted immediately downstream of the Foxp3 ATG translational start site by homologous recombination into a 188-kb mouse BAC (from the C57BL/6 genome; clone RP23-143D8) carrying the intact Foxp3 gene was used. The CNS1 enhancer in Foxp3 gene was deleted by another round of homologous recombination. The modified BAC was purified and microinjected into the pronuclei of a (B6xB6D2) F1 mouse fertilized ovum to generate transgenic line of mice. Three founder mice were generated and screened for Thy1.1 and endogenous Foxp3 expression.The pound symbol (#) is used when no line is specified and/or lines are pooled.
  • mutations:
  • Insertion
  • synonyms:
  • Foxp3 delta CNS1-Cre,
  • Foxp3 delta CNS1-Cre
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Trail: Allele

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Trail: Allele




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