| First Author | Liu Q | Year | 2017 |
| Journal | Neurosci Lett | Volume | 650 |
| Pages | 1-7 | PubMed ID | 28377324 |
| Mgi Jnum | J:252255 | Mgi Id | MGI:5925157 |
| Doi | 10.1016/j.neulet.2017.03.052 | Citation | Liu Q, et al. (2017) Dcf1 regulates neuropeptide expression and maintains energy balance. Neurosci Lett 650:1-7 |
| abstractText | Neuropeptide Y (NPY) is an important neurotransmitter in the brain that plays a pivotal role in food intake and energy storage. Although many studies have focused on these functions, the regulation of NPY expression remains unclear. Here we showed that dendritic cell factor 1 (Dcf1) regulates NPY expression and maintains energy balance. We found that NPY expression is significantly reduced in the hypothalamus of Dcf1 knockout (Dcf1(-/-), KO) mice. In contrast, Dcf1 overexpression significantly increases NPY expression in the cell line. We also found that Dcf1 acts upstream of the NPY gene to regulate NPY expression and modulates the NPY-NPY receptor 1-GABA signal. Notably, we observed a significant increase in the ATP concentration in Dcf1(-/-) mice, suggesting a greater demand for energy in the absence of Dcf1. We studied the relationship between Dcf1 and NPY and revealed that Dcf1 plays a critical role in energy balance. |
