| First Author | Liu Q | Year | 2017 |
| Journal | Behav Brain Res | Volume | 324 |
| Pages | 51-57 | PubMed ID | 28202411 |
| Mgi Jnum | J:249885 | Mgi Id | MGI:5921693 |
| Doi | 10.1016/j.bbr.2017.01.045 | Citation | Liu Q, et al. (2017) Dopamine and dopamine receptor D1 associated with decreased social interaction. Behav Brain Res 324:51-57 |
| abstractText | Deficits in social interaction are hallmarks of neurological and psychiatric disorders. However, its underlying mechanism is still unclear. Here, we show that the loss of dendritic cell factor 1 (Dcf1) in the nervous system of mice induces social interaction deficiency, autism-like behaviour, and influences social interaction via the dopamine system. Dopamine receptor D1 agonist rescues this social cognition phenotype, and improves short-term plasticity. Together, this study presents a new genetic mechanism that affects social interaction and may provide a new way to improve positive social interaction and treat autism spectrum disorders. |
