| First Author | Wang RJ | Year | 2017 |
| Journal | Genetics | Volume | 206 |
| Issue | 4 | Pages | 1841-1852 |
| PubMed ID | 28576862 | Mgi Jnum | J:245093 |
| Mgi Id | MGI:5914944 | Doi | 10.1534/genetics.117.202382 |
| Citation | Wang RJ, et al. (2017) Genetics of Genome-Wide Recombination Rate Evolution in Mice from an Isolated Island. Genetics 206(4):1841-1852 |
| abstractText | Recombination rate is a heritable quantitative trait that evolves despite the fundamentally conserved role that recombination plays in meiosis. Differences in recombination rate can alter the landscape of the genome and the genetic diversity of populations. Yet our understanding of the genetic basis of recombination rate evolution in nature remains limited. We used wild house mice (Mus musculus domesticus) from Gough Island (GI), which diverged recently from their mainland counterparts, to characterize the genetics of recombination rate evolution. We quantified genome-wide autosomal recombination rates by immunofluorescence cytology in spermatocytes from 240 F2 males generated from intercrosses between GI-derived mice and the wild-derived inbred strain WSB/EiJ. We identified four quantitative trait loci (QTL) responsible for inter-F2 variation in this trait, the strongest of which had effects that opposed the direction of the parental trait differences. Candidate genes and mutations for these QTL were identified by overlapping the detected intervals with whole-genome sequencing data and publicly available transcriptomic profiles from spermatocytes. Combined with existing studies, our findings suggest that genome-wide recombination rate divergence is not directional and its evolution within and between subspecies proceeds from distinct genetic loci. |
