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Allele : Gt(ROSA)26Sor<tm2(tTA,tetO-APOE_i4,-EGFP)Gbu> gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Guojun Bu
Primary Identifier  MGI:6119699 Allele Type  Targeted
Attribute String  Conditional ready, Inducible, Inserted expressed sequence, Reporter Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  Not Specified
Induced With  doxycycline/tetracycline Is Recombinase  false
Is Wild Type  false
molecularNote  A construct consisting of a floxed neo cassette, tTA site, a CMV promoter with a tetracycline responsive element, a human APOE_i4 cDNA, an IRES site and an EGFP gene, was inserted via homologous recombination. In the absence of Cre-mediated recombination the human protein is not expressed. Following Cre-mediated recombination the human protein is expressed and this expression may be suppressed with the addition of doxycycline.
  • mutations:
  • Insertion
  • synonyms:
  • iE4,
  • iE4
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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