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Allele : Tg(Plp1-Eif2ak3*)18Pop transgene insertion 18, Brian Popko
Primary Identifier  MGI:6116281 Allele Type  Transgenic
Attribute String  Inducible, Inserted expressed sequence Gene  Tg(Plp1-Eif2ak3*)18Pop
Strain of Origin  C57BL/6J Induced With  tacrolimus
Is Recombinase  false Is Wild Type  false
molecularNote  This transgene consists of 2.4 kb of the 5' flanking DNA, exon 1, and intron 1 of the mouse proteolipid protein driving oligodendrocyte-specific expression of the Eif2alpha kinase effector domain of Eif2ak3 fused to a polypeptide containing two modified FK506 binding domains. The activity of the kinase is dependent on the FK506 dimerizing agent AP20187. RT-PCR and Western blot confirmed the expression of mRNA and protein in the CNS and oligodendrocytes, respectively. Seven lines were established.
  • mutations:
  • Insertion
  • synonyms:
  • PLP/Fv2E-PERK,
  • PLP/Fv2E-PERK
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