| First Author | Solé M | Year | 2004 |
| Journal | Brain Res | Volume | 1020 |
| Issue | 1-2 | Pages | 204-9 |
| PubMed ID | 15312804 | Mgi Jnum | J:92007 |
| Mgi Id | MGI:3051456 | Doi | 10.1016/j.brainres.2004.05.107 |
| Citation | Sole M, et al. (2004) Bcl-2 overexpression does not promote axonal regeneration of the entorhino-hippocampal connections in vitro after axotomy. Brain Res 1020(1-2):204-9 |
| abstractText | CNS lesions trigger cell death in injured neurons and glia. Genes of the bcl-2 family play crucial roles in the control of apoptosis and cell survival in the CNS. Recently, it has been suggested that overexpression of bcl-2 induces axonal elongation and regeneration in vitro and in vivo. Here, we analyze the regenerative potential of bcl-2 overexpression in the axotomized entorhino-hippocampal connection in organotypic slice cocultures. Our results show that in slice cocultures from bcl-2-overexpressing mice, there is a decrease in the number of dead neurons in the entorhinal cortex. In addition, axonal regeneration is not enhanced after axotomy. Thus, in the entorhino-hippocampal formation in vitro, bcl-2 overexpression rescues neurons from axotomy-induced cell death but fails to enhance the regeneration of the entorhino-hippocampal connection. |
