| Primary Identifier | MGI:6159268 | Allele Type | Targeted |
| Attribute String | Hypomorph | Gene | Zfp36 |
| Transmission | Germline | Strain of Origin | C57BL/6 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette, loxP site and mutant exon 2 with a T377C mutation resulting in a C116R substitution were inserted downstream of exon 2 via homologous recombination. Cre mediated recombination removed exon 2 and the neo cassette. The mutation in exon 2 is in the first zinc finger and abrogates binding to RNA in in vitro assays. Expression levels of the mutant protein are similar to wild-type expression levels. |
