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Allele : Umod<tm1.1Rvt> uromodulin; targeted mutation 1.1, Rajesh V Thakker

Primary Identifier  MGI:6116661 Allele Type  Targeted
Gene  Umod Transmission  Germline
Strain of Origin  (129X1/SvJ x 129S1/Sv)F1-Kitl<+> Is Recombinase  false
Is Wild Type  false
description  Phenotypic Similarity to Human Syndrome: autosomal dominant tubulointerstitial kidney disease J:242593.
molecularNote  Homologous recombination introduced the C125R mutation in exon 3 and a loxP flanked neomycin resistance cassette in intron 2. The floxed neomycin cassette was removed via Cre-mediated recombination. The C125R mutation alters the third cysteine residue of the calcium-binding epidermal growth factor-like domain 3.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • Umod<125R>,
  • Umod<125R>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

3 Carried By

Trail: Allele

0 Driven By

6 Publication categories

Trail: Allele