Primary Identifier | MGI:6159129 | Allele Type | Targeted |
Attribute String | Conditional ready, Inserted expressed sequence | Gene | Gt(ROSA)26Sor |
Transmission | Germline | Strain of Origin | Not Specified |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The targeting construct inserted into the locus a CAG promoter, loxP-flanked transcriptional STOP cassette, and a mutant mouse Slc39A14 with a T to G mutation at position 1535 resulting in a lucine to arginine substitution at amino acid 438 (L438R). Cre-mediated recombination is necessary to remove the STOP cassette and get expression of the mutant protein. |