| Primary Identifier | MGI:6148219 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(RHD)1Goo |
| Strain of Origin | C57BL/6 x SJL | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | A human BAC (BAC H0193H09 from the CEPH) carrying RHD gene was used to make transgenic mice. Transcripts from the human gene are detected, but no protein expression was detected with a panel of anti-RhD monoclonal antibodies recognizing different epitopes or a polyclonal anti-RhD. Human RhD protein is not expressed in mouse erythroid cells in the absence of human RHAG despite the presence of murine Rhag. In the presence of human RHAG, a low level of human RHD is detectable. |
