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Allele : Dmd<em1Eno> dystrophin, muscular dystrophy; endonuclease-mediated mutation 1, Eric N Olson

Primary Identifier  MGI:6163634 Allele Type  Endonuclease-mediated
Attribute String  Null/knockout Gene  Dmd
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
molecularNote  CRISPR/Cas9 technology generated a 245 bp deletion that completely eliminated exon 50. DNA sequencing of RT-PCR products confirmed deletion of exon 50, which places the gene out of frame. Western blot analysis confirmed absence of protein in skeletal muscle and heart.
  • mutations:
  • Intragenic deletion
  • synonyms:
  • deltaEx50,
  • deltaEx50
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories

Trail: Allele