| First Author | Bahitham W | Year | 2016 |
| Journal | Biochim Biophys Acta | Volume | 1861 |
| Issue | 5 | Pages | 482-90 |
| PubMed ID | 26976727 | Mgi Jnum | J:250690 |
| Mgi Id | MGI:6104447 | Doi | 10.1016/j.bbalip.2016.03.009 |
| Citation | Bahitham W, et al. (2016) Liver-specific expression of carboxylesterase 1g/esterase-x reduces hepatic steatosis, counteracts dyslipidemia and improves insulin signaling. Biochim Biophys Acta 1861(5):482-90 |
| abstractText | Ces1g/Es-x deficiency in mice results in weight gain, insulin resistance, fatty liver and hyperlipidemia through upregulation of de novo lipogenesis and oversecretion of triacylglycerol (TG)-rich lipoproteins. Here, we show that restoration of Ces1g/Es-x expression only in the liver significantly reduced hepatic TG concentration accompanied by decreased size of lipid droplets, reduced secretion of very low-density lipoproteins and improved insulin-mediated signal transduction in the liver. Collectively, these results demonstrate that hepatic Ces1g/Es-x plays a critical role in limiting hepatic steatosis, very low-density lipoprotein assembly and in augmenting insulin sensitivity. |
