| Primary Identifier | MGI:6199456 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Mecp2 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A point mutation was created in exon 4 (c.965 C>T; coordinates refer to human e2 isoform) to change codon 322 from proline to leucine (p.P322L or p.Pro322Leu). This mutation is associated with human Rett syndrome. The loxP site flanked neomycin resistance gene and STOP cassette that was inserted into intron 2 was removed through subsequent cre-mediated recombination. |
