Primary Identifier | MGI:6200913 | Allele Type | Transgenic |
Attribute String | Inducible, Inserted expressed sequence, Reporter | Gene | Tg(tetO/CMV-Dek,-luc)317Siwe |
Strain of Origin | FVB/N | Induced With | doxycycline/tetracycline |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The transgene is designed with a bidirectional tetracycline operator (tetO; also called tetracycline-responsive element (TRE, TetRE) or tet-operator), Bi-L-Tet, located between two cytomegalovirus (CMV) minimal promoters in the opposite orientation. One CMV promoter drives expression of the murine DEK oncogene (DNA binding) gene (Dek) followed by a polyA signal, while the other CMV reporter drives expression of a luciferase (luc) reporter followed by a simian virus 40 (SV40) polyadenylation (polyA) signal. |