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Allele : Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc transgene insertion 1, David C Chan
Primary Identifier  MGI:6198713 Allele Type  Transgenic
Attribute String  Inserted expressed sequence, Reporter Gene  Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
molecularNote  The Mnx1 (homeobox HB9) promoter drives the expression of a C-terminally Myc-tagged mouse mitofusin 2 with the T105M mutation found in families with Charcot-Marie-Tooth disease type 2A followed by an IRES and an EGFP in motor neurons. Western blot analysis with an anti-Myc antibody confirmed expression of the transgene. Sequence analysis of the insertion site indicates that the transgene inserted into a non-coding region on chromosome 11 between genes Rad51c and Ppm1e.
  • mutations:
  • Insertion
  • synonyms:
  • Tg1Mfn2<T105M>,
  • Mfn2<T105M>,
  • Mfn2<T105M>,
  • Tg1Mfn2<T105M>
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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0 Driven By

3 Publication categories

Trail: Allele




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