| First Author | Toth LA | Year | 1996 |
| Journal | J Interferon Cytokine Res | Volume | 16 |
| Issue | 12 | Pages | 1065-72 |
| PubMed ID | 8974010 | Mgi Jnum | J:38004 |
| Mgi Id | MGI:85397 | Doi | 10.1089/jir.1996.16.1065 |
| Citation | Toth LA (1996) Strain differences in the somnogenic effects of interferon inducers in mice. J Interferon Cytokine Res 16(12):1065-72 |
| abstractText | Increased slow-wave sleep accompanies influenza infection in C57BL/6 mice but not BALB/c mice, These strains of mice possess different alleles of the genetic locus If-1, which codes for high (If-1(h); C57BL/6) and low (If-1(1); BALB/c) production of interferon (IFN), a putative sleep- inducing cytokine, To evaluate the contribution of the If- 1 gene to differences in murine sleep propensity, sleep patterns were evaluated in mice treated with the IFN inducers polyinosinic:polycytidilic acid (pIC) or Newcastle disease virus (NDV), with influenza virus, or with murine interferon (IFN-alpha) or IFN-alpha/beta. As compared with baseline values, C57BL/6 mice exhibited increased slow-wave sleep after all three challenges, but BALB/c mice did not, Congenic B6.C-H28(c) mice, which bear the BALB/c allele for low IFN production on the C57BL/6 genetic background, showed enhanced slow-wave sleep after influenza infection but not after NDV, Exogenous IFN did not enhance slow-wave sleep in either C57BL/6 or BALB/c mice, These data suggest that the If-1 allele may influence the somnogenic responsiveness of mice under some conditions but that additional mechanisms may contribute to sleep enhancement during infectious disease. |
