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Allele : Tg(Myh6/tetO-Thbs4*)929Jmol transgene insertion 929, Jeffery Molkentin
Primary Identifier  MGI:6196024 Allele Type  Transgenic
Attribute String  Inducible, Inserted expressed sequence Gene  Tg(Myh6/tetO-Thbs4*)929Jmol
Strain of Origin  FVB/N Induced With  doxycycline/tetracycline
Is Recombinase  false Is Wild Type  false
molecularNote  Mutations in six DxDxDG calcium binding motifs (D499/501/503A, D512/514/516A, D571/573/575A, D632/634/636A, D655/557/659A, and D668/670/672A) within the T3R domains of mouse Thbs4 are under the control of a minimally active mouse alpha myosin heavy chain (Myh6) promoter fused to seven copies of the tetracycline-responsive promoter element (tetO). To make the Myh6 promoter minimally active, three GATA sites and two thyroid-like response elements are ablated.
  • mutations:
  • Insertion,
  • Nucleotide substitutions
  • synonyms:
  • Thbs4-mCa<2+>,
  • Thbs4-mCa<2+>
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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0 Driven By

4 Publication categories

Trail: Allele




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