| Primary Identifier | MGI:6196027 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Mecp2 |
| Transmission | Germline | Strain of Origin | C57BL/6NTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 3 was targeted with a G>A mutation changing codon 106 from arginine to glutamine (p.Arg106Gln or p.R106Q) in the DNA-binding domain of the encoded peptide. An FRT site flanked neomycin resistance gene cassette that was inserted into intron 3 was subsequently removed through flp-mediated recombination. This allele mimics a human mutation associated with Rett syndrome. |
