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Allele : Ighg1<em1Durw> immunoglobulin heavy constant gamma 1 (G1m marker); endonuclease-mediated mutation 1, Duane R Wesemann
Primary Identifier  MGI:6195842 Allele Type  Endonuclease-mediated
Attribute String  Not Specified Gene  Ighg1
Transmission  Germline Strain of Origin  129S6/SvEvTac
Is Recombinase  false Is Wild Type  false
molecularNote  With sgRNAs targeting the mu and gamma1 switch regions in the Igh-C immunoglobulin heavy chain constant region, the intervening sequence was deleted in ES cells using CRISPR/Cas9 technology. This engineered recombination (deleting the Ighm, Ighd, and Ighg3 segments) mimics an IgG1 class-switch.
  • mutations:
  • Intragenic deletion
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Trail: Allele

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