| Primary Identifier | MGI:6196148 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Klra1 |
| Transmission | Germline | Strain of Origin | C57BL/6NTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A loxP site flanked neomycin resistance gene cassette was inserted into intron 4. A substitution was engineered in exon 4 that changed codon 8 from tyrosine to phenylalanine (p.Tyr8Phe or p.Y8F). This mutation disrupts the cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) of the peptide, effectively creating a knock-out. The neo cassette was removed through subsequent cre-mediated recombination. |
