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Allele : Gabrg2<em1Menn> gamma-aminobutyric acid type A receptor, subunit gamma 2; endonuclease-mediated mutation 1, Steven Mennerick
Primary Identifier  MGI:6209490 Allele Type  Endonuclease-mediated
Attribute String  Not Specified Gene  Gabrg2
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
molecularNote  Codon 269 was targeted with single-stranded oligodeoxynucleotide (ssODN) donor DNAs, sgRNAs and Cas9 using CRISPR/Cas9 technology. All components were microinjected into the cytoplasm and pronuclei of fertilized eggs. The resulting p.T269Y (p.Thr269Tyr) mutation renders the receptor picrotoxin (PTX) resistant without affecting basal receptor function.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • gamma2* KI,
  • gamma2* KI
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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