| Primary Identifier | MGI:6257026 | Allele Type | Targeted |
| Attribute String | Conditional ready | Gene | Pole |
| Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A floxed puromycin with a splice acceptor, four SV40 polyadenylation sequences and splice donor was inserted upstream of exon 8. Exon 9 was modified with a C to G point mutation to induce the amino acid substitution of arginine for proline at position 286 (P286R). This mutation is present in human cancers and leads to error-prone DNA replication. |
