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Allele : Gt(ROSA)26Sor<tm1(H1/tetO-RNAi:Fxn)Dhg> gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Daniel H Geschwind
Primary Identifier  MGI:6220715 Allele Type  Targeted
Attribute String  Inducible, Knockdown, RMCE-ready Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  129
Induced With  doxycycline/tetracycline Is Recombinase  false
Is Wild Type  false
description  LW-4 ES cells = 129SvEv
molecularNote  A short hairpin RNA directed against the frataxin gene was targeted into the Rosa26 locus. The shRNA sequence is under the regulation of the tetO operator and a codon optimized tet repressor (itetR) under the control of the CAG promoter. The construct was transfected into LW-4 ES cells through Recombinase Mediated Cassette Exchange
  • mutations:
  • Insertion
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1 Mutation Involves

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