| Primary Identifier | MGI:6256806 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inducible, Inserted expressed sequence | Gene | Tg(tetO-EGFR*)#Kkw |
| Strain of Origin | FVB/N | Induced With | doxycycline/tetracycline |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Seven direct repeats of the tetracycline operator sequence drive the inducible expression of the human EGFR with the T790M mutation and deletion of exon 19 (del E746_A750). Mice with this transgene that express the tetracycline transactivator (tTA) or reverse transactivator (rtTA) under the control of a tissue-specific promoter can be induced to express the mutant gene in tissues or cell types of interest by administration/withdrawal of doxycycline. |
